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Kolbe–Schmitt reaction
The Kolbé–Schmidt reaction or Kolbe process (named after Hermann Kolbe and Rudolf Schmitt) is a carboxylation chemical reaction that proceeds by heating sodium phenolate (the sodium salt of phenol) with carbon dioxide under pressure (100 atm, 125 °C), then treating the product with sulfuric acid. The final product is an aromatic hydroxy acid which is also known as salicylic acid (the precursor to aspirin).〔 (Review)〕
By using potassium hydroxide, 4-hydroxybenzoic acid is accessible, an important precursor for the versatile paraben class of biocides used e.g. in personal care products.
==Reaction mechanism==
The Kolbe–Schmitt reaction proceeds via the nucleophile addition of a phenoxide, classically sodium phenoxide (NaOC6H5), to carbon dioxide to give the salicylate.
The final step is reaction of the salicylate with acid to form the desired salicylic acid.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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